Vico Therapeutics strengthens its Board along with raising $31m Series A financing co-led by Life Science Partners and Kurma Partners

– NETHERLANDS, Leiden – Vico Therapeutics, a Leiden, the Netherlands, based biotech company focusing on the development of RNA modulating therapies for rare neurological disorders, today announced that it has raised $31 million (€27 million) in a Series A financing round led by Life Science Partners, co-led by Kurma Partners, and supported by Pontifax, Droia Genetic Disease, Polaris Partners and Pureos Bioventures and Idinvest Partners.

Vico’s Board will consist of:

  • Martijn Keijwegt, Managing Partner of LSP,
  • Felice Verduyn-van Weegen, Investment Manager LSP,
  • Rémi Droller, Managing Partner Kurma Partners,
  • Silvia Noiman, Pontifax,
  • Luc Dochez, Managing Partner, Droia Genetic Disease,
  • Amy Schulman, Managing Partner Polaris Partners
  • Anja Harmeier, Partner Pureos Bioventures
  • Josh Mandel-Brehm, co-founder.

Vico will use this funding to further advance its late preclinical stage Antisense OligoNucleotides lead platform for the development of therapies for different forms of Spinocerebellar Ataxia and Huntington Disease into first-in-human clinical trials in late 2021. Its early discovery RNA editing platform is directed towards RETT syndrome.

Vico’s lead asset is an investigational AON therapy targeting expanded trinucleotide repeats that translate into abnormally long and toxic polyglutamine stretches in proteins that cause a series of neurodegenerative polyQ disorders like Spinocerebellar Ataxia type 1, type 3 and Huntington’s disease.

It has been demonstrated to preferentially reduce the levels of mutant polyQ compared to wildtype proteins. This was confirmed in several established mouse models for SCA1, SCA3 and Huntington Disease, with a long-term and widespread distribution of the compound throughout the central nervous system. Based on these encouraging data combined with the broad applicability of the lead compound to multiple different brain disorders with high unmet medical need, Vico is advancing this program towards a first-in-human trial expected in late 2021.

Luc Dochez, Founder and Chairman of Vico Therapeutics, stated: “This Series A funding will allow us to advance our lead program into the clinic and continue to build our capabilities as a leader in the development of novel therapies for serious CNS disorders. We see tremendous potential to advance the field and apply the breadth of our antisense oligonucleotide expertise to address severe neurological disorders. We are looking forward to accelerating the development of our platform technologies around AON technology and RNA-modulation/editing to bring best-in-class therapies to patients. The Vico team built this company around a unique synergy between state-of-the-art molecular biology, AON chemistry laboratories and industry experience in successfully developing drugs based on AON technology.”

Martijn Kleijwegt, managing partner at LSP, lead investor and board member, added: “Vico is building a leading team and has a cutting-edge infrastructure to engineer best-in-class therapies for severe neurological conditions and accelerate their advancement into human clinical trials. A major strength of Vico’s approach is the broad applicability to different polyQ diseases and the selectivity for mutant proteins.”

About Vico Therapeutics

Vico Therapeutics is a Leiden, the Netherlands, based biotech company focusing on the development of RNA modulating therapies for rare severe neurological disorders. Vico’s antisense oligonucleotide platform is focusing on different forms of Spinocerebellar Ataxia and Huntington Disease. Its early discovery RNA editing platform is directed towards RETT syndrome.

Vico was founded in 2019 by highly experienced entrepreneurs Luc Dochez and Josh Mandel-Brehm and seasoned scientists Dr. Judith van Deutekom and Dr. Gail Mandel with strong academic reputations and vast industry experience.

For more information: https://vicotx.com/

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