– USA, CA – eFFECTOR Therapeutics (NASDAQ: EFTR), a leader in the development of selective translation regulator inhibitors for the treatment of cancer, today announced the appointment of Dr. Barbara Klencke (M.D.) to its board of directors.
Dr. Klencke is Chief Medical Officer and Chief Development Officer at Sierra Oncology.
“Dr. Klencke is a phenomenal leader with an extensive track record of success in oncology drug development, from R&D through approval and commercialization. Her expertise will be invaluable to eFFECTOR as we expand our clinical development and operational capabilities. We are thrilled to be working with her and grateful for the opportunity to benefit from her insights as we work to providing better outcomes to patients in need.,” commented CEO, Steve Worland.
The company also announced that Dr. Larry Lasky has resigned from the board of directors.
About Dr. Barbara Klencke
Dr. Klencke has over 28 years of experience in oncology across strategic roles at biopharmaceutical companies and leading academic institutions. She currently serves as Chief Medical Officer and Chief Development Officer of Sierra Oncology, a late-stage biopharmaceutical company focused on delivering targeted therapies that treat rare forms of cancer. She previously served as SVP of Development at Onyx Pharmaceuticals, before and after its acquisition by Amgen, with responsibility for the development pipeline including Kyprolis (carfilzomib). Before her position at Onyx, she served as Group Medical Director in Product Development, Oncology, at Genentech. In this period, she led a variety of oncology programs including those for Kadcyla (ado-trastuzumab emtansine), Avastin (bevacizumab), and Tarceva (erlotinib). Before that, Dr. Klencke served as the Medical Director at Chiron Corporation, a biotechnology company later acquired by Novartis International AG, and as an assistant professor of medicine at the University of California, San Francisco Medical Center. She holds a B.S. from Indiana University and an M.D. from the University of California, Davis.
“eFFECTOR has made significant progress to date and in my opinion has all of the makings to set new standards of patient care through its platform of novel STRI candidates,” said Dr. Klencke. “I look forward to working with eFFECTOR and its seasoned board of directors to expand its already broad horizons as we advance toward the common goal of providing much-needed therapies to cancer patients.”
About eFFECTOR Therapeutics
eFFECTOR is a clinical-stage biopharmaceutical company focused on pioneering the development of a new class of oncology drugs referred to as STRIs. eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase interacting kinase. The eIF4F complex is a central node where two of the most frequently mutated signaling pathways in cancer, the PI3K-AKT, and RAS-MEK pathways, converge to activate the translation of select mRNA into proteins that are frequent culprits in key disease-driving processes. Each of eFFECTOR’s product candidates is designed to act on a single protein that drives the expression of multiple functionally related proteins, including oncoproteins and immunosuppressive proteins in T cells, that together control tumor growth, survival, and immune evasion. eFFECTOR’s lead product candidate, tomivosertib, is an MNK inhibitor currently being evaluated in KICKSTART, a randomized, double-blind, placebo-controlled Phase 2b trial of tomivosertib in combination with pembrolizumab in patients with metastatic non-small cell lung cancer. Zotatifin, eFFECTOR’s inhibitor of eIF4A, is currently being evaluated in Phase 2a expansion cohorts in certain biomarker-positive solid tumors, including ER+ breast cancer and KRAS-mutant NSCLC. eFFECTOR has a global collaboration with Pfizer to develop inhibitors of a third target, eIF4E. In addition to the company’s oncology focus, zotatifin is being evaluated as a potential host-directed antiviral therapy in patients with mild to moderate COVID-19 in collaboration with the University of California, San Francisco, under a $5 million grant sponsored by the Defense Advanced Research Projects Agency.
For more information: https://effector.com/
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